A new name in thrombosis, ADAMTS13
نویسندگان
چکیده
منابع مشابه
A new name in thrombosis, ADAMTS13.
T thrombocytopenic purpura (TTP) is a rapidly fatal illness, first described by Moschowitz in 1924 (1), that is characterized by anemia, a low platelet count (thrombocytopenia), and microvascular thrombosis. The anemia is caused by hemolysis and is associated with sharply pointed red cell fragments, termed schistocytes, that look as though they might have been sliced with a knife. The thrombocy...
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No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without permission from the author or, when appropriate, from publishers of the publications. Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus " The World is a book, and those who do not travel, only read a ...
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von Willebrand factor (VWF) levels are elevated and a disintegrin-like and metalloprotease with thrombospondin type I repeats-13 (ADAMTS13) activity is decreased in both acute and chronic inflammation. We hypothesized that by cleaving hyperactive ultralarge VWF (ULVWF) multimers, ADAMTS13 down-regulates both thrombosis and inflammation. Using intravital microscopy, we show that ADAMTS13 deficie...
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Deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), a VWFcleaving protease, is the key factor in the pathogenesis of thrombotic thrombocytopenic purpura (TTP), a life-threatening thrombotic microangiopathy. It is well established that ADAMTS13 deficiency results in elevated plasma levels of ultralarge VWF multimers (ULVWF), which are prone...
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The name Miconia densiflora Cogn. (1886) is a later homonym of Miconia densiflora (Gardner) Naudin (1851), but since we propose it as a taxonomic synonym of Miconia caudata (Bonpl.) DC. (1828), we do not provide a new name. The name Miconia longicuspisHerzog (1909) is a later homonym of Miconia longicuspis Cogn. (1891) and we here propose its replacement by Miconia longicuspidata S.S. Renner & ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.192448999